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August 24, 2024International Journal of Biological MacromoleculesOpen Access

Supramolecular complexes of GCAP1: Implications for inherited retinal dystrophies

Amedeo Biasi Valerio Marino Giuditta Dal Cortivo Daniele Dell’Orco

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Abstract

Guanylate Cyclase Activating Protein 1 (GCAP1) is a calcium sensor that regulates the enzymatic activity of retinal Guanylate Cyclase 1 (GC1) in photoreceptors in a Ca

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Biasi et al. (2024) studied this question.

synapsesocial.com/papers/68e5b130b6db64358754a376 https://doi.org/10.1016/j.ijbiomac.2024.135068

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supramolecular complexes of GCAP1: towards the development of effective biologics for inherited retinal dystrophies2024
2Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditionsOriginal Research · 2026 · 3 citations
3Constitutive Activation of Photoreceptor Guanylate Cyclase by Y99C Mutant of GCAP-1In Vitro Study · 1998 · 156 citations
4NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation2024 · 1 citations
5Allosteric Communication of the Dimerization and the Catalytic Domain in Photoreceptor Guanylate Cyclase2024 · 1 citations

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