Assessment of Serum Amyloid A in Healthy Children

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Background: Serum amyloid A (SAA) is a major conserved and sensitive acute phase protein that is highly expressed in response to inflammation and tissue injury. High levels of SAA are associated with several chronic inflammatory diseases, and may also be a potential biomarker of several malignancies. This work aimed to to assess SAA level in apparently healthy children.Methods: This cross-sectional study was carried out on 85 healthy children, aged 8-11 years old, from outpatient clinic of benha university hospital and c. All included children were subjected to detailed history taking, general examination, local examination and investigations including C-reactive protein (CRP) and SAA.Results: There was no statistical difference in the level of serum amyloid A regarding their sex but there was statistical difference in the level of serum amyloid A regarding their age, increasing significantly in older children. There was a significant positive correlation between serum Amyloid A and age, also there was a significant positive correlation between SAA and both BMI, and CRP level .Conclusions: The mean SSA among healthy children were 2.2±0.7. It wasn't differ by sex, but increase gradually with age. There was a significant positive correlation between SSA and (age, BMI and CRP).