Optically active phthalides are prevalent in many natural and bioactive products.Herein, a novel dynamic kinetic resolution of iso-benzofuranone derivatives through palladium-catalyzed asymmetric allylic alkylation has been developed to synthesize phthalide de-rivatives bearing vicinal quaternary and tertiary stereocenters with high yields, showing excellent regio-, enantioand diastereoselec-tivity.Furthermore, gram-scale experiment underwent smoothly and the transformation of product could build a bridged bicyclic skeleton.
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Liu et al. (2024) studied this question.
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