Chemical synthesis study demonstrates simultaneous creation of chiral phosphorus and quaternary carbon centers via palladium catalysis, highlighting an efficient enantioselective reaction cascade.
A palladium-catalyzed asymmetric tandem Heck and carbonylation of bisallyl-phosphine oxides has been developed. This desymmetrization process provided an efficient route to the simultaneous synthesis of a chiral P-stereogenic center and a chiral quaternary carbon stereocenter in good yields with good diastereo- and enantioselectivities.
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Zhou et al. (2024) studied this question.
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