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August 23, 2024Brain Behavior & Immunity - HealthOpen Access

Lower medial prefrontal cortex connectivity with the nucleus accumbens at rest relates to HIV+ status, monocyte expression of TNF-a and perceived psychological stress

Roger McIntosh Judith D. Lobo Angela Szeto Manuel Hidalgo Michael A. Kolber

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Abstract

Post-menopausal persons living with HIV (PWH) report elevated levels of psychological stress and monocyte activation compared to persons living without HIV (PWOH). Resting state functional connectivity (rsFC) of mesolimbic brain regions underpinning stress and emotion regulation are susceptible to inflammatory insult. Although psychological stress is elevated, rsFC reduced, and CD16

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McIntosh et al. (2024) studied this question.

synapsesocial.com/papers/68e5b28db6db64358754bcca https://doi.org/10.1016/j.bbih.2024.100844

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Psychological stress is associated with arterial inflammation in people living with treated HIV infectioncross-sectional · 2023 · 21 citations
2Brain function abnormalities and neuroinflammation in people living with HIV-associated anxiety disorders2024 · 7 citations
3Ventromedial prefrontal cortex connectivity during and after psychological stress in womenother · 2019 · 31 citations
4Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disordersOriginal Research · 2025 · 1 citations
5Elevated inflammation in people with HIV is associated with aberrant neural oscillations serving selective attentionOriginal Research · 2026

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