Synthetic study demonstrates copper-catalyzed coupling of SF4 alkynes with tetrahydroisoquinolines, highlighting broader substrate scope for drug discovery.
We present a viable approach for the cross-dehydrogenative coupling of Het-SF4-alkynes with tetrahydroisoquinolines under oxidative conditions, using TBHP and copper catalysts. These newly developed conditions boast enhanced yields and a more extensive range of substrates, demonstrating tolerance to various functional groups and addressing the limitations of earlier reports. Consequently, this method should increase opportunities for the exploration of SF4-containing compounds and their potential applications in drug discovery, materials science, and as alternatives to PFAS.
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Narra et al. (2024) studied this question.
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