( N Engl J Med . 2024;390(12):1069-1079. DOI: 10.1056/NEJMoa2309359) Maternal use of valproate during pregnancy has been linked to a heightened risk of neurodevelopmental disorders in children. While most studies on other antiseizure medications did not show increased risks of these disorders, insufficient and inconsistent data exist regarding the risk of autism spectrum disorder (ASD) associated with maternal topiramate use. A study conducted on maternal use of antiseizure medications during pregnancy, particularly focusing on the risk of ASD in children, revealed noteworthy findings.
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Hernández–Dı́az et al. (2024) studied this question.
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