August 22, 2024Biological ResearchOpen Access

Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology

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GluN1 subunit expression drops selectively across hippocampal synaptic populations at 12 months, showing layer-dependent loss in CA1, CA3, and dentate gyrus.
Quantitative SDS-FRL and histoblot assays mapped GluN1 density across seven excitatory synapse classes in 12-month-old APP/PS1 mice and wild-type controls.
Highlights targeted vulnerability of hippocampal NMDA receptors during Aβ pathology, driving circuit disruption in an APP/PS1 mouse model; further work needed.

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Implication

Preclinical study demonstrates layer-specific loss of synaptic GluN1 in APP/PS1 mice, suggesting localized receptor vulnerability underlies network dysfunction.

Cite This Study

Alfaro‐Ruiz et al. (2024) studied this question.

synapsesocial.com/papers/68e5b4dfb6db64358754d689 https://doi.org/10.1186/s40659-024-00537-7

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Implication

Preclinical study demonstrates layer-specific loss of synaptic GluN1 in APP/PS1 mice, suggesting localized receptor vulnerability underlies network dysfunction.

Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology

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Discussion

Implication

Cite This Study

Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology

Key Points

Discussion

Implication

Cite This Study

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