Efficacy of Self-assembling Peptide P11-4 in Remineralizing In Vitro Caries-like Lesions in Primary Enamel Samples in Combination with Calcium Phosphate-based Remineralization Agents

regeneration strategy to regenerate hydroxyapatite crystals in the subsurface was required. 4elf-assembling peptides, P11-4 (CH3CO-Gln-Gln-Arg-Phe-Gln-Trp-Gln-Phe-Gln-Gln-GlnNH2), the recent advancement in the field of regenerative medicine, are used for regenerating tooth tissues on smooth surfaces. 5This peptide, which is commercially available IntroductIonLiterature-based studies have demonstrated the value of fluoride in preventing dental cavities and continue to assert that fluoride is still the gold standard for preventing caries lesions.Salivary remineralization, however, is also shown to be restricted to the tooth's outer 30 μm.The esthetic or structural aspects of the underlying lesion are not improved by this surface-only remineralization. 1 Fluorides have a notable penetrating effect on healthy enamel, but they are less effective on lesions that have developed into carious lesions. 1 Due to their similarity to natural enamel, calcium phosphates were shown to be a viable biomimetic alternative in the field of remineralization.It is thought that calcium phosphate acts by penetrating the microscopic pores of developing carious lesions, where it serves as crystal nuclei in the remineralization process by persistently drawing significant volumes of calcium and phosphate ions into the lesion, thereby accelerating natural remineralization processes. 2Manufacturers of the existing calcium-phosphatebased remineralization systems declare that these calcium phosphate systems help to supply calcium and phosphate ions for the remineralization process. 3owever, since these conventional materials could not integrate with biological systems through a cellular pathway, a true