LINC00651, A Long Non-Coding RNA, Acts as a Catalyst in the Progression of Breast Cancer by Promoting Proliferation, Migration, and Invasion

Introduction: The incidence of Breast Cancer (BC), a prevalent malignancy in women, has gone up recently, although the molecular pathways underlying the carcinogenesis of BC are still unknown. Long non-coding RNAs (lncRNAs) have become important tumor progression regulators. Method: The present study has revealed increased expression of LINC00651 in BC tissues through a thorough investigation of whole-transcriptome resequencing on matched BC and normal tissues from 8 patients. It is yet unknown precisely as to what biological function LINC00651 serves in BC. To obtain further insight, 39 matched pairs of breast tumors and normal tissues underwent Real-time quantitative Polymerase Chain Reaction (RT-qPCR) for validation. The validated cohort's clinicopathologic characteristics were then carefully examined. Following short interfering RNA transfection, proliferation, colony formation, migration, invasion, and examination of phenotypes associated with the Epithelial-mesenchymal Transition (EMT) were conducted in BC cell lines (MDA-MB-231 and BT-549). Results: Our findings have confirmed that LINC00651 plays a role in augmenting BC cell lines' proliferation, migration, and invasion. Consequently, LINC00651 can be considered a potential new therapeutic target for BC treatment. Conclusion: As breast cancer remains a significant health concern, understanding its molecular underpinnings is crucial for developing effective treatments. The identification of LINC00651 as a promoter of BC cell growth and metastasis has suggested that it could be a promising target for future therapeutic interventions, potentially offering new avenues for improved patient outcomes.