An optimised procedure for histological assessment of cartilage damage

Cartilage damage is often caused by degeneration and injury. Delaying detection and treatment can exacerbate degeneration, leading to impaired joint function. Due to the avascular and nerveless nature of cartilage tissue, completely repairing hyaline cartilage remains a challenge for researchers. Besides, assessing the damage grades and the effectiveness of treatment for cartilage damage is very important.Despite various non-invasive longitudinal monitoring methods such as ultrasound and magnetic resonance imaging, histopathology remains the “gold standard” for assessing joint cartilage quality. However, research on cartilage histopathology in Vietnam is still not commonly conducted. This research aims to establish an efficient, implementable, and reliable evaluation process for cartilage histopathology in humans and experimental animals.