The Potential Renoprotective Effects of Ticagrelor in Rhabdomyolysis-Induced Acute Kidney Injury in Rat

Background: Rhabdomyolysis is a potentially lethal range of symptoms results from muscle cell destruction. It is recognized by the escape of cell contents such as myoglobin, creatine kinase, and electrolyte into the bloodstream then undergo glomeruli filtering. Therefore, among the most dangerous complication of rhabdomyolysis is acute renal injury. The complex and interrelated processes underlying rhabdomyolysis that ends with acute kidney injury include obstruction and damage of tubules, inflammation, and intrarenal vasoconstriction (activation of the sympathetic, renin-angiotensin).Glycerol is frequently used to inflict this kind of harm when used as a single dose injection that given intramuscularly to an animal model.