What is the clinical evidence from this study?

Study design: Other. Population: Rhabdomyolysis.

What does this research mean for the field?

Combination therapy with statins and fibrates can induce severe rhabdomyolysis leading to acute renal tubular damage potentiated by factors such as volume depletion and hypoperfusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 2002Clinical Chemistry

Rhabdomyolysis-related Renal Tubular Damage Studied by Proton Nuclear Magnetic Resonance Spectroscopy of Urine

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Key result

Review details the pathophysiology of rhabdomyolysis linked to statin and fibrate therapy.

Why the study?

The pathophysiology of renal injury in rhabdomyolysis-related acute renal failure is not fully understood, including factors beyond muscle damage that contribute to tubular necrosis.

Design

Other

Authors

EBEleni BairaktariUniversity of Ioannina KSKonstantin SeferiadisUniversity of Ioannina GLGeorgé LiamisUniversity of Ioannina

Discussion

Member takes

Implication

Lacks quantitative data on statin-fibrate rhabdomyolysis risk; leaves open the need for prospective studies.

PICO

Population

Rhabdomyolysis

Cite This Study

Bairaktari et al. (2002) studied Rhabdomyolysis. The abstract discusses the pathophysiology of rhabdomyolysis and its association with statin and fibrate therapy, but reports no quantitative study results.

synapsesocial.com/papers/6aaa2b6c5205089cd0a4e8a0 https://doi.org/10.1093/clinchem/48.7.1106

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Rhabdomyolysis-related Renal Tubular Damage Studied by Proton Nuclear Magnetic Resonance Spectroscopy of Urine

Discussion

Member takes

Implication

PICO

Cite This Study

Rhabdomyolysis-related Renal Tubular Damage Studied by Proton Nuclear Magnetic Resonance Spectroscopy of Urine

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider