Iodonium Salt‐Mediated Oxidation of Sulfides to Sulfoxides by DMSO

Compounds bearing the sulfoxide moiety display an important class of molecules in pharmaceutical industry. Many efforts have been made towards the development of novel, sustainable, easy‐to‐execute and industrially friendly processes. A novel iodonium‐salt‐mediated oxidation protocol for the conversion of sulfides into the corresponding sulfoxides is reported, employing DMSO as the oxidant. Several sulfides decorated with various functional groups were tested, leading to the corresponding products in good to excellent yields with remarkable chemoselectivity. The oxidation protocol was successfully applied to the synthesis of the pharmaceutical active ingredients (APIs) Sulforaphane and Modafinil.