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August 20, 2024BiochemistryOpen Access

How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase

Michael A. Funk Christina M. Zimanyi Gisele A. Andree Allison E. Hamilos Catherine L. Drennan

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Abstract

Class Ia ribonucleotide reductases (RNRs) are allosterically regulated by ATP and dATP to maintain the appropriate deoxyribonucleotide levels inside the cell for DNA biosynthesis and repair. RNR activity requires precise positioning of the β

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Funk et al. (2024) studied this question.

synapsesocial.com/papers/68e5b8a1b6db643587551216 https://doi.org/10.1021/acs.biochem.4c00329

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