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August 20, 2024Reproductive Biology and Endocrinology8 citationsOpen Access

Single-cell RNA sequencing reveals the effects of high-fat diet on oocyte and early embryo development in female mice

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QZQi ZhuFLFeng LiHWHao Wang

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Abstract

Obesity is a global health issue with detrimental effects on various human organs, including the reproductive system. Observational human data and several lines of animal experimental data suggest that maternal obesity impairs ovarian function and early embryo development, but the precise pathogenesis remains unclear.

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Cite This Study

Zhu et al. (2024) studied this question.

synapsesocial.com/papers/68e5b8a1b6db6435875513d2https://doi.org/10.1186/s12958-024-01279-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development2024 · 18 citations
  2. 2Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice2024 · 7 citations
  3. 3Preconception Diet Interventions in Obese Outbred Mice and the Impact on Female Offspring Metabolic Health and Oocyte Quality2024 · 2 citations
  4. 4Obesogenic diet alters decidual differentiation and cell-cell communication in the mouse uterus2025
  5. 5Single-cell transcriptomic profiling of the early developing endometrium to understand the impacts of maternal obesity2026