How effective are antioxidants without fetal hemoglobin in tackling oxidative stress in sickle cell disease?

In our previous work titled “Antioxidative potential of foetal haemoglobin in sickle cell disease”, we reported that fetal hemoglobin correlated directly with antioxidative markers and inversely with markers of oxidative stress in sickle cell subjects. Based on our observations, we concluded that fetal hemoglobin contributes to the cellular antioxidant defense system by limiting the rate of production of reactive oxygen species. In this current report, we aim to highlight the synergy between fetal hemoglobin and the antioxidant defense system in modulating oxidative stress in sickle cell disease.