Reliable multi‐modal medical image‐to‐image translation independent of pixel‐wise aligned data

The current mainstream multi-modal medical image-to-image translation methods face a contradiction. Supervised methods with outstanding performance rely on pixel-wise aligned training data to constrain the model optimization. However, obtaining pixel-wise aligned multi-modal medical image datasets is challenging. Unsupervised methods can be trained without paired data, but their reliability cannot be guaranteed. At present, there is no ideal multi-modal medical image-to-image translation method that can generate reliable translation results without the need for pixel-wise aligned data.