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August 16, 2024Synfacts

HRO761: a First-in-Class Non-Covalent WRN Inhibitor with Synthetic Lethality in MSI Cancers

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Abstract

Key words WRN - synthetic lethality - MSI cancers - non-covalent WRN inhibitor - first-in-class inhibitor - HRO761 - clinical candidates

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Cite This Study

A 2024 study studied this question.

synapsesocial.com/papers/68e5bfacb6db6435875578ce https://doi.org/10.1055/s-0043-1773367

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers2024 · 134 citations
2Targeting werner helicase with synthetic lethality in microsatellite instability cancers: Promising therapeutic approaches2024 · 2 citations
3Abstract 6590: Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells2024
4Abstract 5141: ZMS-4084, a potent and selective WRN inhibitor induces significant tumor regression and sustained complete responses in MSI-H tumor modelsIn Vitro Study · 2026
5Abstract B020: Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells2024