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August 16, 2024Synfacts

Regioselective Difluoromethylation of Pyridines through Oxazino-pyridine Intermediates

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Abstract

Key words Minisci reaction - difluoromethylation - meta-selectivity - para-selectivity - pyridines - redox-neutral - oxazino-pyridines

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Cite This Study

A 2024 study studied this question.

synapsesocial.com/papers/68e5bfacb6db643587557944 https://doi.org/10.1055/s-0043-1775044

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch2024 · 55 citations
2(Chloromethyl)triisopropoxysilane Enables Highly Regioselective N1-Methylation of Pyrazoles2024
3Solvent-Selective C-H Fluorination and Alkylative Dimerization of Pyrazolo[1,5-a]pyrimidines by Utilizing the Dual Role of Selectfluor as an Electrophilic Fluorinating Reagent and OxidantOriginal Research · 2026
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5Iridium‐Catalyzed Enantioselective Formal <i>meta</i>‐Allenylation of Pyridines2025 · 13 citations