Preclinical study demonstrates sex-specific microbiome alterations in allergen-induced mice, highlighting the need to evaluate sex variables in asthma pathogenesis.
Recent evidence has demonstrated that the microbiome is a driver of the underlying pathophysiological mechanisms of respiratory disease. Studies have indicated that bacterial metabolites produced in the gut and lung can impact lung inflammation and immune cell activity, affecting disease pathology. Despite asthma being a disease with marked sex differences, experimental work linking microbiomes and asthma has not considered the sex variable.
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Ekpruke et al. (2024) studied this question.
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