Coxsackievirus A24 variant whole genome sequencing from clinical samples using a three overlapping amplicons strategy

Q: What type of study is this?

This is a Experimental Study study.

John Mwita Morobe; Samuel Odoyo; Arnold W. Lambisia; Edidah Moraa; Charlotte J. Houldcroft; Edward C. Holmes; George Githinji; Charles N. Agoti

doi:10.12688/wellcomeopenres.24183.2

October 6, 2025Wellcome Open ResearchOpen Access

Coxsackievirus A24 variant whole genome sequencing from clinical samples using a three overlapping amplicons strategy

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Key Points

The study recovered three near complete genomes of coxsackievirus A24 variant from acute hemorrhagic conjunctivitis cases.
A novel whole genome sequencing assay was developed specifically for the coxsackievirus A24 variant.
This genomic sequencing method may enhance research for epidemiology studies on coxsackievirus A24 variant.
The findings from Kenya could provide insights into the evolution of coxsackievirus A24 variant in future outbreaks.

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Implication

Investigation reveals coxsackievirus A24 variant as the cause of AHC in Kenya, suggesting new genomic sequencing methods could enhance surveillance.

Abstract

<ns3:p>In January 2024, the Kenya Ministry of Health issued an outbreak alert following a surge in acute hemorrhagic conjunctivitis (AHC) cases along the Kenyan coast. Our investigations identified coxsackievirus A24 variant (CV-A24v) as the causative agent. In this study, we developed a novel whole genome sequencing assay for CV-A24v, and used it to recover three near complete genomes from the 2024 AHC outbreak in Kenya. This method will support future studies on CV-A24v genomic epidemiology and evolution across Kenya and beyond.</ns3:p>

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Cite This Study

Morobe et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1ba6950a706b22b5373 https://doi.org/10.12688/wellcomeopenres.24183.2

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Coxsackievirus A24 variant whole genome sequencing from clinical samples using a three overlapping amplicons strategy

Key Points

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Implication

Abstract

Discussion

Cite This Study

Coxsackievirus A24 variant whole genome sequencing from clinical samples using a three overlapping amplicons strategy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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