This review explores ozone therapy's biochemical properties and clinical applications, indicating a need for randomized controlled trials.
Ozone therapy is an evolving medical modality within naturopathy, integrative medicine and regenerative healthcare. Therefore, it is of interest to review synthesizes historical development, biochemical properties, mechanisms of action, administration methods and clinical applications. Thus, the need for multicentred randomized controlled trials, exploration of molecular mechanisms including epigenetic effects and integration with regenerative medicine is highlighted.
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Anthony et al. (2025) studied this question.
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