Case report demonstrates effective reparative regeneration in tibia fracture, suggesting potential for new biomaterials.
INTRODUCTION: The incidence of consolidation disorders in long bone fractures remains high worldwide and shows no tendency to decline. Currently, a search for and development of new biomaterials aimed at activating and accelerating reparative regeneration of damaged tissues, is ongoing. Unfortunately, many regulatory compounds are tissue-specific and do not produce a comprehensive effect on regeneration. AIM: To demonstrate a clinical case of stimulation of reparative regeneration in case of impaired consolidation of a tibia fracture using an original method. The article describes a clinical case of a closed spiral fracture of the middle third of tibia and closed comminuted fracture of the upper third of fibula with displacement of fragments after a road accident. On clinical examination of the patient at 1 month after stimulation according to the original method, a complete absence of pain syndrome, walking without additional supporting means, and full range of motion in the limb joints were noted. Control radiographs at 4 months after the surgery showed consolidation of the tibia fracture. CONCLUSION: The use of the original method of stimulating reparative regeneration in the form of local injection therapy with Cortexin® drug for delayed consolidation of a tibia fracture demonstrated a positive effect, however, a small amount of accumulated experience requires further study.
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Gusev et al. (2025) studied this question.
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