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Synthesis of carnosic acid derivatives with ester and carbamate groups shows anticancer potential in colorectal cancer, suggesting further research is warranted.
Novel derivatives of carnosic acid 1 with ester or carbamate groups at C-20 and derivatives with these functional groups combined with benzylic modifications (C-7) were synthesized and evaluated in a colorectal cancer cell line (HCT116).
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Moura et al. (2025) studied this question.
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