β-caryolane derivatives as novel anti-colorectal cancer agents: synthesis and in vitro biological evaluation

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This is a In Vitro Study study.

Xingjun Xu; Zhiwei Wang; Anjie Huang; Zhiguang Qiao; Yonglin Ge; Hui Wen; Junxiang Cheng; Yaopeng Zhao; Jingyu Yan

doi:10.1039/d5ra07312j

January 1, 2025RSC AdvancesOpen Access

β-caryolane derivatives as novel anti-colorectal cancer agents: synthesis and in vitro biological evaluation

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Key Points

The research aims to explore the synthesis of novel β-caryolane derivatives and their anti-colorectal cancer effects.
Synthesis of β-caryolane derivatives via acid catalysis.
In vitro biological evaluation of synthesized compounds.
Compound NC-19 exhibits anti-CRC activity.
Induces apoptosis by arresting the cell cycle at the G0/G1 phase.
Elevates intracellular ROS levels.

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Implication

Compound NC-19 demonstrates anti-colorectal cancer activity by inducing apoptosis, suggesting potential therapeutic use.

Abstract

Novel β-caryolane derivatives were synthesized via acid catalysis. Compound NC-19 exhibited anti-CRC activity by arresting the cell cycle at the G0/G1 phase, elevating intracellular ROS levels, and thereby inducing apoptosis.

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/6940ac893507a57a7f7a37e6 https://doi.org/10.1039/d5ra07312j

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β-caryolane derivatives as novel anti-colorectal cancer agents: synthesis and in vitro biological evaluation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

β-caryolane derivatives as novel anti-colorectal cancer agents: synthesis and in vitro biological evaluation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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