October 8, 2025HippocampusOpen Access

Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors

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This minireview highlights drug engrams and synaptic plasticity in addiction, suggesting pathways for reducing relapse.

Drug-related memories are strongly resistant to extinction, leading to persistent drug-seeking behaviors.
Research shows that addiction-related memories are encoded by drug engrams, which are affected by synaptic and molecular plasticity.
Engram tagging techniques help identify addiction-specific neural circuits, influencing relapse outcomes.
Interventions targeting drug engrams could reduce relapse triggers and enhance protective circuits against addiction.

Cutler et al. (2025) studied this question.

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