October 8, 2025MedicineOpen Access

Exploring the causal role of gut microbiota and inflammatory proteins in neuromyelitis optica spectrum disorder: A Mendelian randomization study with mediation analysis

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ZYZiqian YinSoochow University YQYoujia QiuSoochow University YYYayi YangSoochow University

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Implication

Mendelian randomization study found causal links between gut microbiota and neuromyelitis optica spectrum disorder, suggesting inflammatory proteins do not mediate this relationship.

Key Points

A causal relationship is established between gut microbiota and neuromyelitis optica spectrum disorder (NMOSD).
Mendelian randomization revealed significant associations of specific gut microbiota and inflammatory proteins with NMOSD risk.
Sensitivity analyses confirmed the robustness of the findings, although inflammatory proteins were not mediators in the gut microbiota-NMOSD pathway.
The study enhances understanding of the interplay between gut microbiota and NMOSD, indicating potential directions for future research.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1be6950a706b22b5827 https://doi.org/10.1097/md.0000000000043967

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Implication

Mendelian randomization study found causal links between gut microbiota and neuromyelitis optica spectrum disorder, suggesting inflammatory proteins do not mediate this relationship.

Exploring the causal role of gut microbiota and inflammatory proteins in neuromyelitis optica spectrum disorder: A Mendelian randomization study with mediation analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Exploring the causal role of gut microbiota and inflammatory proteins in neuromyelitis optica spectrum disorder: A Mendelian randomization study with mediation analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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