October 8, 2025MedicineOpen Access

Causal relationship between plasma metabolites and hypertension: A Mendelian randomization study

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Mendelian randomization shows causal links between metabolites and hypertension, suggesting metabolic impacts.

Findings suggest that certain plasma metabolites causally impact hypertension, with alterations in their levels potentially influencing blood pressure.
The inverse variance weighting method calculated significant effects of various metabolites on hypertension, including significant confidence intervals for each metabolite's impact.
Utilizing data from genome-wide association studies, researchers analyzed metabolites from over 2,000 varieties to assess their relationship with hypertension.
These results may highlight key pathways involved in hypertension, indicating that further research is essential to unravel the biological mechanisms at play.

Yang et al. (2025) studied this question.

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