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This is a Literature Review study (also classified as: Experimental Study, Animal Study).

October 8, 2025

Mechanisms of therapeutic action of monoclonal antibodies to the calcitonin gene-related peptide (CGRP) ligand-receptor system in migraine

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Review of therapeutic mechanisms of anti-CGRP monoclonal antibodies in migraine, highlighting their pharmacodynamics and implications.

Monoclonal antibodies targeting CGRP demonstrate significant potential in the prevention of migraine.
Experimental studies indicate the effectiveness of anti-CGRP antibodies and receptor antagonists in reducing migraine frequency.
The trigeminovascular theory underscores the role of CGRP in migraine pathogenesis, informing treatment strategies.
Pharmacodynamics of CGRP-targeting drugs offer insights into innovative treatment approaches for chronic migraine.

Alexey Y. Sokolov (2025) studied this question.

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