The article presents a description of a clinical case of atypical late form of pantothenate kinase-associated neurodegeneration (PKAN) in the terminal stage with debut in the fourth decade of life and rapidly progressive course. The most characteristic signs of the disease in this patient were parkinsonism syndrome, pyramidal symptoms, various hyperkinesis, decreased cognitive functions, depression. The diagnosis was based on the characteristic clinical picture and typical MRI signs in the form of the “tiger eye” symptom. Due to the lack of eff ective treatment methods at present, the patient received symptomatic treatment.
No takes yet. Share an insight, caveat, or question.
Новикова et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: