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October 8, 2025Prospects in Pharmaceutical SciencesOpen Access

Elucidating Neuropharmacological Implications of Vincetene: A Multi-target Computational Study on Ataxia, Encephalitis, and Meningitis

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Authors

APA PrameelaDepartment of BiotechnologyARArunkumar RadhakrishnanEngineering Arts (United States)TKThenmozhi KrishnasamyDepartment of Biotechnology

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Overview

Computational analysis reveals vincetene's potential against ataxia and encephalitis, suggesting multi-target neuroprotective effects.

Key Points

  • Vincetene shows potential as a neurotherapeutic agent, exhibiting strong binding to proteins related to ataxia and encephalitis.
  • A bioavailability score of 0.55 indicates favorable pharmacokinetics, with elevated absorption and blood-brain barrier permeability.
  • Network pharmacology identifies 49 relevant genes linked to vincetene and a range of neurological disorders.
  • Molecular docking studies show vincetene's stable binding to key proteins involved in neuronal survival and stress response.

Cite This Study

Prameela et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1c36950a706b22b5c03https://doi.org/10.56782/pps.490
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