MRI histogram analysis of tumor-infiltrating CD8+ T cell levels in patients with glioblastoma

CD8+ T cell infiltration in tumors is a powerful predictor of the clinical and postoperative prognosis of GBM patients. Immunohistochemical staining was used to assess tumor-infiltrating CD8+ T cell expression in patient-derived tumor tissue samples. Histogram analysis of GBM was performed using Firevoxel software. Among the T1C histogram features, the CV, mean, 5th, 10th, 25th, and 50th percentiles were correlated with the levels of CD8+ T cells. The ROC curve analysis revealed that the CV had the highest AUC value (0.783). Histogram analysis is an efficient non-invasive imaging modality for the prediction of tumor-infiltrating CD8+ T cells in glioblastoma.