Histogram analysis of APT Combined with DTI and DSC MRI for Predicting IDH Mutation and MGMT promotor methylation Status in Glioma

In this study, the diagnostic performance of histogram features of APT, DTI and DSC in predicting IDH mutation and MGMT promoter methylation status of gliomas was compared. Secondly, the histogram parameters from the signal-time intensity curve of DSC significantly improved the predictive performance of DSC model. Most importantly, the combined logistic regression model combined with APT, DTI and DSC can evaluate the tumor nature of glioma more comprehensively and obtain better diagnostic performance, which is expected to become an imaging molecular marker for the prediction of glioma genotyping in the future.