Elevated Carotid Pulse Wave Velocity is associated with Cognitive Impairment and Brain Amyloid Deposition

Increasing evidence suggests that vascular compliance could offer valuable insights into the pathology of Alzheimer’s diseases. Recently, carotid pulse wave velocity (cPWV) between internal carotid artery and common carotid artery has been successfully measured by a fast single-slice oblique-sagittal PC-MRI technique. In this study, we evaluated the role of cPWV in brain amyloid deposition and cognitive decline in an aged cohort. The results showed that greater cPWV was associated with cognitive decline and amyloid pathology. Our findings suggest elevated cPWV may affect amyloid clearance in brain, leading to cognitive impairment. cPWV could be a potential sensitive imaging marker of AD.