Key result
Carotid-femoral pulse wave velocity was significantly correlated with carotid intima media thickness (r = 0.3222, P = 0.0315), but not with the severity of carotid stenosis.
Why the study?
Does carotid-femoral pulse wave velocity correlate with angiographic carotid atherosclerosis in elderly patients?
Observational (n=103)
Does carotid-femoral pulse wave velocity correlate with angiographic carotid atherosclerosis in elderly patients?
Effect estimate: r = 0.3222
p-value: p=0.0315
Carotid-femoral pulse wave velocity correlates positively with carotid intima-media thickness in elderly patients, suggesting its potential utility as a marker for early carotid atherosclerosis.
Supports PWV evaluation as early atherosclerosis marker in elderly; leaves open its role in stenosis assessment pending prospective data.
OBJECTIVE: To investigate the relationship between the pulse wave velocity (PWV) and angiographic carotid atherosclerosis in elderly patients. METHOD: 103 consecutive elderly patients were divided into two groups according to the results of cerebral angiography: carotid atherosclerosis group and normal carotid angiogram group. Basic clinical information was required by a standardized questionnaire. Carotid-femoral PWV (cfPWV) as a marker of Stiffness of artery was measured, Carotid intima media thickness (IMT) and carotid stenosis degree in angiography was evaluated. Independent-sample t test was used to evaluate the difference in cfPWV between the two groups, Bivariate associations between cfPWV and an index of extracoronary atherosclerosis (IMT and severity of stenosis) was performed. RESULT: Among 103 subjects, 55 with carotid atherosclerosis and 48 with a normal carotid angiogram, a significant difference between the two groups in IMT and PWV was found (P<0.05), and the cfPWV was significantly correlated with IMT (r = 0.3222, P = 0.0315), but not severity of carotid stenosis (r = 0.1573, P = 0.3137). CONCLUSION: cfPWV showed a positive correlation to carotid IMT, and maybe is a potentially useful adjunctive atherosclerotic risk marker to Identify of early carotid atherosclerosis.
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Shen et al. (2011) conducted an observational in Carotid atherosclerosis (n=103). Carotid atherosclerosis vs. Normal carotid angiogram was evaluated on Correlation between carotid-femoral pulse wave velocity (cfPWV) and carotid intima media thickness (IMT) (r = 0.3222, p=0.0315). Carotid-femoral pulse wave velocity was significantly correlated with carotid intima media thickness (r = 0.3222, P = 0.0315), but not with the severity of carotid stenosis.
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