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Parkinson’s disease (PD) is a progressive neurodegenerative disease with motor dysfunction and cognitive impairments frequently. Previous studies indicated that diffusion MRI could detect white matter alteration in the brain, which can be correlated with disease severity. We use diffusion MRI to investigate the relationship between cognitive functions and these plasma biomarkers. Our study showed that the involved regions might play important roles in early cognitive decline as related to the pathological deposition of the respective plasma biomarkers. This observation might help to elucidate the early pathological change of the brain contributing to different cognitive declines in PD patients.
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Tsai et al. (2024) studied this question.
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