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Presented novel phosphorus- and fluorine-containing polymer possess high sensitivity at 31P/19F-MR and a large chemical shift from biological phosphorus signal (∆δ=60 ppm) due to phosphorothioate P=S group in its structure. The probe represents a conceptually new approach for phosphorus MR, as it undergoes oxidation-induced structural changes in the presence of ROS, represented in greater amounts in cancer tissue. The additional 19F-MR signal serve as an on-site information on the polymer distribution in the organism.
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Ziółkowska et al. (2024) studied this question.
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