Accelerated Enhanced Simultaneous Single-Quantum and Triple-Quantum-Filtered Sodium MRI Using Compressed Sensing at 7T

Enhanced simultaneous single-quantum and triple-quantum-filtered imaging of 23Na (SISTINA) enables images to be weighted towards restricted sodium, a promising biomarker for clinical practice, but suffers from long acquisition times and low image quality. However, this can be alleviated by applying compressed sensing (CS). This work establishes a novel enhanced SISTINA sequence using FLORET sampling at 7T and demonstrates that CS can accelerate SISTINA acquisitions with less noise and better structure preservation than non-uniform fast Fourier transform while maintaining proper weightings towards total, non-restricted, and restricted sodium. The reduced acquisition time facilitates the clinical transition of enhanced SISTINA.