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The study investigated age-related neuromelanin signal variation and iron content changes in the subregions of substantia nigra simultaneously by magnetization transfer contrast neuromelanin-sensitive multi-echo fast field echo sequence in a normal population. We manually delineated neuromelanin, iron deposition regions and the overlap regions. The correlation analysis revealed contrast ratio increased over age, while volume showed an age-related decline in the overlap region which were similar to those in the neuromelanin region. No significant correlations were found between susceptibility and age in any subregion. This study may provide more insight for the future degenerative elucidations of substantia nigra.
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Chen et al. (2024) studied this question.
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