Neuromelanin MRI signal decreases in IPD patients in the substantia nigra. In this study, we investigated that the decrease is caused by not only the reduction of neuromelanin but also iron deposition. Neuromelanin reduction in IPD patients was shown by the result of the substantia nigra volume decrease. The comparison result of contrast ratio, calculated between substantia nigra and crus cerebri, of IPD patients versus healthy controls demonstrated that iron deposition also decreases the signal of NM-MRI. T2*, susceptibility, and overlapped area between substantia nigra from neuromelanin MRI and hypo-intense area from SMWI also represented the tendency of iron deposition.
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Kim et al. (2024) studied this question.
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