We investigated the relationship between subregions of the substantia nigra and behavioral disinhibition in patients with Parkinson disease using neuromelanin MRI. We found a significant positive relationship between disinhibition and neuromelanin MRI contrast ratio in bi-lateral clusters localized in the medial substantia nigra. These findings suggest that neuromelanin MRI can be used to assess the localization of changes in the substantia nigra and inform how dopamine pathophysiology relates to behavioral symptoms in Parkinson disease.
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Trujillo et al. (2024) studied this question.
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