Recent advances of the cBOLD technique by means of dual-gas calibration have shown its ability in producing baseline OEF and CMRO2 in absolute physiologic units. A recently proposed constrained qBOLD method has shown its feasibility in proper separation of numerous confounders, yielding physiologically plausible values for both Yv and DBV across the entire brain. The purpose of this work was to compare the two oximetric techniques, dual-gas cBOLD versus constrained qBOLD, in terms of measured OEF and CMRO2 at baseline. Results suggest that the two methods yield statistically insignificant differences in OEF and CMRO2 quantifications for GM regions.
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Lee et al. (2024) studied this question.
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