Intravoxel incoherent motion diffusion weighted imaging to assess brain microstructure and perfusion in patients with end-stage renal disease

This study aimed to investigate the clinical value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in evaluating the brain microstructural and perfusion changes in end-stage renal disease (ESRD) patients. 40 ESRD patients and 30 healthy subjects were recruited in this study and underwent IVIM MRI. The microstructure and perfusion of the brain showed significantly differences in the left frontal lobe, bilateral temporal lobe, left hippocampus, right occipital lobe, represented by IVIM derived parameters of slow apparent diffusion coefficient (ADCslow) and fast apparent diffusion coefficient (ADCfast). Therefore, we concluded that the brain microstructure and perfusion were impaired in ESRD patients.