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Low immune infiltrates severely hinder cancer immunotherapy. Hence, we developed a manganese-phenolic networks platform (TMPD) The TMPD was based on doxorubicin (DOX) loaded PEG-PLGA nanoparticles and further coated with manganese (Mn)-tannic acid (TA) networks. Mechanistically, DOX could kill cancer cells while Mn2+ could significantly increase the activity of STING pathway related protein to amplify the STING signal and has the function of MRI T1 imaging. The nanoplatform could promote the presentation of tumor antigens and activate a robust innate and adaptive immunity, providing reference for the application of molecular imaging in tumor diagnosis and treatment.
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Pang et al. (2024) studied this question.
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