manganese-based nanosystem for dual-modality imaging guided STING pathway with immunotherapy against triple-negative breast cancer

Due to the high incidence and mortality rate, breast cancer has become the major cause of cancer death among females. This study reports a kind of functional nanocomposite, which was designed to comprises Pluronic F127 to self-assembly manganese carbonyl (MnCO) and IR780 dyes into one system, exhibiting NIR-II and MR dual-modal imaging guided STING pathway and anti-tumor immunity against triple-negative breast cancer.