Radiomics Features of Infrapatellar Fat Pad Associated With Post-Traumatic Osteoarthritis at 10+ Years After Acl Reconstruction

ACL injury is a major risk factor for post-traumatic osteoarthritis (PTOA), however mechanisms are not fully understood. In this work, we use radiomics from quantitative MRI imaging to associate subvisual changes in the infrapatellar fat pad (IPFP) to both symptomatic and radiographic PTOA. MRI was collected from 113 patients at least 10 years post-ACLR. 1690 radiomics and 11 clinical features were extracted and selected using a gradient-boosted decision tree classifier model. A subset of texture-associated features of IPFP and no clinical features were associated with symptomatic PTOA with an AUROC of 0.74 and radiographic PTOA with an AUROC of 0.84.