Association between Post-traumatic Osteoarthritis 10+ Years after ACLR and Quantitative MRI of Knee Cartilage, Menisci, and Thigh Muscles

The purpose of this study was to evaluate the associations between radiomic features in knee and thigh quantitative MRI with symptomatic and radiographic post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction (ACLR). Radiomic features of knee cartilage, menisci (extracted from T1ρ maps), and thigh muscles (extracted from anatomic images and fat fraction maps) were extracted from patient MRI 10+ years after ACLR, and features were selected for symptomatic or radiographic PTOA associations. Symptomatic and radiographic PTOA were associated with features from the medial cartilage compartments, and menisci; features from the thigh muscles were associated with symptomatic PTOA only.