Early monitoring of radiation treatment based on tumor redox status using in vivo dynamic nuclear polarization MRI

In vivo dynamic nuclear polarization-MRI (DNP-MRI, also called OMRI, PEDRI) using carbamoyl-PROXYL(CmP) as a redox sensitive DNP probe enables the accurate monitoring of the tissue redox status. We found that the redox status decreases 1 day after radiation treatment, and the decay of redox status occurs before any micro- or macroscopic changes in tumor morphology and pyruvate metabolism based on the Warburg effect. This decay of redox status can also be associated with the decreased production of intratumor reducing redox molecules such as GSH and AsA.