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It has been unclear whether metabolic-functional coupling could be disturbed in epileptogenic lesion and network by epileptic activities. In this study, we investigated metabolic changes, functional alterations and their couplings in epileptogenic lesion and network of mesial temporal lobe epilepsy (MTLE) using simultaneous PET/MR, and further evaluated the relationship between altered couplings and surgical outcome. MTLE patients showed abnormalities of standardized uptake value ratio (SUVR) and fractional amplitude of low-frequency fluctuation (fALFF) in default mode network (DMN). MTLE patients with hippocampal sclerosis (MR-HS) had higher SUVR-fALFF coupling in ipsilateral hippocampus and DMN, and the couplings were associated with surgical outcomes.
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Yuan et al. (2024) studied this question.
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